World’s First Breath Based NanoSensor Technology for Digital Medicine

AiroStotle™ by nGageIT Digital Health is a revolutionary digital breath biomarker sensor capable of early-stage disease detection and cancerous recurrence monitoring.

Designed to overcome a variety of challenges that have confounded prior approaches to breath-based biopsies and early-stage cancer and disease detection, AiroStotle™ can with a single breath detect digital biomarkers of cancerous tumours’ breath signatures with high clinical sensitivity and specificity. Digital biomarkers are based on nGageIT Digital Health’s proprietary market-leading sensor technology and VOC nanoparticle library.
It is well know that in many cases up to 40% of cancerous tumours don’t shed their genetic fragments into the bloodstream confounding many genetic blood based modalities (liquid biopsies) and limiting them to later stages of cancer detection.
AiroStotle enables accurate reporting of known cancer and disease biomarkers from the breath at the earliest stages (stage 0), localizing the tumor to its internal organ site, while filtering out biological noise sources that typically confound traditional blood based genetic testing.

“The metabolism of people with lung cancer, pancreatic cancer and breast cancer is different to that of healthy people and this is reflected in the chemical signature of their breath.”

The AiroStotle™ custom built NanoSensor array has the ability to detect disease in the exhaled breath which can expand the scope of precision oncology to earlier stages of the disease, improving patient outcomes and lower healthcare costs.

AiroStotle™ has the ability to improve stage-at-diagnosis rates by enabling physicians and primary care providers to detect and diagnose cancers at much earlier stages, improving recovery and life expectancy rates and saving lives.

Airostotle™ is being designed and developed to execute tests that enable clinicians to detect disease and recurrence at a stage when intervention may have a higher chance to cure . It is also designed to help bio-pharmaceutical customers identify new opportunities in adjuvant drug development and therapies targeting earlier stage cancers.

 

AiroStotle by nGageIT Digital Health turns breath into data.

Endogenous volatile organic compounds (VOCs) are released within the human organism as a result of normal metabolic activity or due to pathological disorders. They enter the bloodstream and are eventually metabolized or excreted via exhalation, skin emission, urine, etc.
Breath sampling is non-invasive and breath samples can be extracted as often as desired.[1]
Identification and quantification of potential disease biomarkers can be seen as the driving force for the analysis of exhaled breath. Moreover, future applications for medical diagnosis and therapy control with dynamic assessments of normal physiological function or pharmacodynamics are intended.

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AiroStotle™ breath-based disease detection versus leading biopsy detection methods

DISEASE DETECTION

Current liquid biopsy disease detection methods can support detection of up to 60% of cancerous tumors. AiroStotle™ by nGageIT Digital Health can detect at least 90% of cancerous tumors when they are present.

0%
Liquid Biopsy Detection Rate Up to 60% of all cancers
0%
AiroStotle Breath-Based Detection Rate At least 90% of all cancers
STAGE DETECTION

Current liquid biopsy disease detection methods support detecting up to 60% of cancerous tumors only when they are at a late stage of development ie stage 3, stage 4, or beyond. AiroStotle™ by nGageIT Digital Health can detect over 90% of cancerous tumors at their earliest stage (stage 0) when they are present.

Liquid Biopsy 30%
Detects late-stage cancers only
AiroStotle Breath-Based Detection Rate 90%
Detects cancers at earliest stage (stage 0) when they are present
LAB PROCESSING

Current liquid biopsy lab testing processes take up to 2 weeks to process a single sample. AiroStotle by nGageIT Digital Health provides sample test results in near-real-time, taking weeks off of the test processing time.

Liquid Biopsy 14%
Lab processing in 2 weeks time assuming tissue sample can be used
Breath-Based Lab Processing 100%
Lab processing in near-real-time

35 million people in the USA are at high risk of developing Cancer.

Two-thirds of cancers caught early are curable. Of those caught late, 80% are fatal.
Early Cancer screening at checkups is the single biggest diagnostic opportunity in recent history.

Conquering Cancer with Each Breath

AiroStotle™ by nGageIT Digital Health can radically transform healthcare by providing immediate line of sight into disease and cancerous states, enabling earlier diagnoses and improving outcomes for millions of people. 

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